This package facilitates the discovery of biomarkers from biological sequencing data (e.g., microarrays, RNA-seq) based on the associations of potential biomarkers with exposure and outcome variables by implementing an estimation procedure that combines a generalization of moderated statistics with targeted minimum loss-based estimates (TMLE) of causal parameters (e.g., Average Treatment Effect) whose estimators admit asymptotically linear representations (in terms of influence functions).

biotmle()

References

Bioconductor:

https://bioconductor.org/packages/biotmle

Documentation:

https://code.nimahejazi.org/biotmle

GitHub repository:

https://github.com/nhejazi/biotmle