This function prepares next-generation sequencing data (counts) for use with the biomarker TMLE procedure by invoking the voom transform of limma.

rnaseq_ic(biotmle, weights = TRUE, ...)



A bioTMLE object containing next-generation sequencing count data in its "assays" slot.


A logical indicating whether to return quality weights of samples in the output object.


Other arguments to be passed to voom or voomWithQualityWeights as appropriate.


EList object containing voom-transformed expression measures of count data (actually, the mean-variance trend) in the "E" slot, to be passed into the biomarker TMLE procedure.